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JoVE Journal
Chemistry

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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
 

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

Article DOI: 10.3791/56926
February 16th, 2018

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Summary February 16th, 2018

Chiral amino alcohols are versatile molecules for use as scaffolds in organic synthesis. Starting from L-lysine, we synthesize amino alcohols by an enzymatic cascade reaction combining diastereoselective C-H oxidation catalyzed by dioxygenase followed by cleavage of the carboxylic acid moiety of the corresponding hydroxyl amino acid by a decarboxylase.

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