Organ Ischemia-Reperfusion Injury by Simulating Hemodynamic Changes in Rat Liver Transplant Model

Organ ischemia-reperfusion injury by simulating hemodynamic changes in rat liver transplant model. Ischemia-reperfusion injury is a common application after liver transplantation. Patients with extrahepatic organ involvement tend to stay longer in hospital, spend more and haves a worse prognosis.

The development of the complication is closely related to the length of the anhepatic phase of liver transplantation. However, basic research into the ischemia-reperfusion injury after liver transplantation has shown that the survival rate after liver transplantation is inversely related to the degree of injury to extrahaptic organs. Based on the definition of the anhaptic phase, we simulated the hemodynamic change in liver transplantation resulting in ischemia-reperfusion injury of extrahaptic organs.