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Journal / Neuroscience / Høj overførselshastighed analyse af…
JoVE Journal
Neuroscience

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JoVE Journal Neuroscience
Høj overførselshastighed analyse af bevægeapparatet adfærd i Drosophila ø Assay
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Høj overførselshastighed analyse af bevægeapparatet adfærd i Drosophila ø Assay

Article DOI: 10.3791/55892-v • 10:30 min • November 5th, 2017
November 5th, 2017 •
*1, *1, 2, 3, *1, *1
1Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, 2Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 3Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
* These authors contributed equally

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Ø-analysen er en relativt ny, omkostningseffektive assay, der kan bruges til at evaluere grundlæggende bevægeapparatet funktionsmåden for Drosophila melanogaster. Dette manuskript beskriver algoritmer til automatisk databehandling og objektiv kvantificering af øen assay data, hvilket gør dette assay en følsom, høj overførselshastighed udlæsning til store genetiske eller farmakologiske skærme.

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Neurovidenskab spørgsmålet 129 High throughput automatiske kvantificering motor opførsel locomotion flight response sygdomsmodeller bevægelsesforstyrrelser øen assay Drosophila
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