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JoVE Journal Neuroscience
Modellering Amyloid-β42 giftighet og Neurodegeneration i voksen sebrafisk hjernen
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Modellering Amyloid-β42 giftighet og Neurodegeneration i voksen sebrafisk hjernen

Article DOI: 10.3791/56014-v • 10:01 min • October 25th, 2017
October 25th, 2017 •
1, 2, 1, 1, 3, 2, 1,3
1German Centre for Neurodegenerative Diseases (DZNE) Dresden within Helmholtz Association, 2B CUBE, Center for Molecular Bioengineering, Technische Universität Dresden, 3Center for Regenerative Therapies Dresden (CRTD), TU Dresden

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Denne protokollen beskriver syntese, karakterisering og injeksjon av monomerisk amyloid-β42 peptider for generering av amyloid toksisitet i voksen sebrafisk å etablere en Alzheimers sykdom modell, etterfulgt av histologiske analyser og påvisning av samlinger.

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Nevrovitenskap problemet 128 Amyloid β42 sebrafisk neurodegeneration cerebroventricular microinjection Alzheimers sykdom solid fase peptid syntese
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