Journal
/
Chemistry
/
Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface
JoVE Journal
Chemistry
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Chemistry
Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

DOI:
10.3791/56175-v

•

07:00 min

•

August 11, 2017

•

,
1Analytical Research and Development,Novartis Pharmaceuticals Corporation

Chapters

  • 00:05Title
  • 00:46Sample Solution and Coupons Cleaning
  • 02:02Swabbing Procedure
  • 04:07Recovery Calculation
  • 04:46Influence of Coupon Cleaning on Recovery Results
  • 06:11Conclusion

Summary

Automatic Translation

Automatic Translation

The lack of a well-defined procedure that consistently cleaned coupon surfaces was identified as the major contributor to low and variable recoveries in cleaning verification. This manuscript describes the correct protocol of cleaning stainless steel coupons.

Tags

Cleaning VerificationPharmaceutical IndustryStainless Steel SurfaceAnalytical Method DevelopmentCleaning LimitCleaning ApproachHPLC WaterAlkaline DetergentAcid DetergentSwabbingDrug Residue Recovery

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

A Method to Manipulate Surface Tension of a Liquid Metal via Surface Oxidation and Reduction

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Observation and Analysis of Blinking Surface-enhanced Raman Scattering

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Surface Properties of Synthesized Nanoporous Carbon and Silica Matrices

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Read Article