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Journal / Biochemistry / Personalizada péptido matrices para la detección…
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Biochemistry

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JoVE Journal Biochemistry
Personalizada péptido matrices para la detección de aloanticuerpos HLA en trasplante de órganos
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Personalizada péptido matrices para la detección de aloanticuerpos HLA en trasplante de órganos

Article DOI: 10.3791/56278-v • 08:07 min • September 6th, 2017
September 6th, 2017 •
1, 1, 1, 3, 2, 1
1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering, Southeast University

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Desajustes en las secuencias de leucocito humano antígeno (HLA) entre pares de receptores y donante de órganos son la causa principal de rechazo mediada por anticuerpos en el trasplante de órganos. Aquí presentamos el uso de matrices de antígeno personalizados basados en secuencias HLA de donantes individuales para sondear aloanticuerpos HLA de anti-donantes en receptores de órganos.

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Bioquímica número 127 trasplante de órganos rechazo de transplante de anticuerpo mediado (AMR) antígeno humano del leucocito (HLA) desajuste HLA aloanticuerpo matriz de antígeno SPOT síntesis
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