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Biochemistry

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JoVE Journal Biochemistry
Tilpasset peptid matriser for påvisning av HLA Alloantibodies i organtransplantasjon
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Tilpasset peptid matriser for påvisning av HLA Alloantibodies i organtransplantasjon

Article DOI: 10.3791/56278-v • 08:07 min • September 6th, 2017
September 6th, 2017 •
1, 1, 1, 3, 2, 1
1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering, Southeast University

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Uoverensstemmelser i menneskelig leukocytter antigen (HLA) sekvenser mellom organtransplantasjon og mottaker parene er den viktigste årsaken til antistoff-mediert avvisning i organtransplantasjon. Her presenterer vi bruk av egendefinerte antigen matriser som er basert på individuelle givere HLA sekvenser å undersøke anti-giver HLA alloantibodies i orglet mottager.

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Biokjemi problemet 127 organtransplantasjon antistoff mediert transplantasjon avvisning (AMR) menneskelige leukocytter antigen (HLA) HLA misforholdet Alloantibody Antigen array SPOT syntese
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