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JoVE Journal
Immunology and Infection

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Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death
 

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death

Article DOI: 10.3791/56535
October 31st, 2017

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Summary October 31st, 2017

We illustrate a straight-forward method to derive murine primary macrophages from bone marrow cells and a simple method to prepare BSA-fatty acid conjugates. Then we demonstrate that saturated fatty acids can induce macrophage cell death, and such cell death is positively associated with cellular accumulation of ceramide levels.

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