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JoVE Journal Cancer Research
En prekliniske musemodell Osteosarcoma definere den ekstracellulære Vesicle-mediert kommunikasjonen mellom svulst og Mesenchymal stamceller
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En prekliniske musemodell Osteosarcoma definere den ekstracellulære Vesicle-mediert kommunikasjonen mellom svulst og Mesenchymal stamceller

Article DOI: 10.3791/56932-v • 11:15 min • May 6th, 2018
May 6th, 2018 •
*1, *2, 2
1Neuro-oncology Research Group, VU Medical Center, 2Exosomes Research Group, Department of Pathology, VU Medical Center
* These authors contributed equally

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Direkte injeksjon av kreft-avledet ekstracellulære blemmer (EVs) fører til omprogrammering av benmarg støtte svulst progresjon; men er hvilke celler som megle denne effekten uklart. Her beskriver vi en trinnvis protokoll for å undersøke EV-mediert svulst-mesenchymal stamceller (MSC) interaksjoner i vivo, avslører en avgjørende rolle for EV-utdannede MSCs i metastasering.

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Kreftforskning problemet 135 Orthotopic kreft musemodell mesenchymal stamceller ekstracellulære blemmer svulst microenvironment metastasering osteosarcoma
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