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Journal / Cancer Research / Utilizando 18F-FDG PET-CT Imaging e histologia…
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Cancer Research

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JoVE Journal Cancer Research
Utilizando 18F-FDG PET-CT Imaging e histologia quantitativa para medir mudanças dinâmicas no metabolismo glicose em modelos de Mouse de câncer de pulmão
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Utilizando 18F-FDG PET-CT Imaging e histologia quantitativa para medir mudanças dinâmicas no metabolismo glicose em modelos de Mouse de câncer de pulmão

Article DOI: 10.3791/57167-v • 06:51 min • July 21st, 2018
July 21st, 2018 •
1, 2, 3, 3, 3, 1, 4, 5, 1
1Division of Pulmonary and Critical Care Medicine, University of California Los Angeles David Geffen School of Medicine, 2University of North Carolina at Chapel Hill, 3Department of Molecular and Medical Pharmacology, University of California Los Angeles, 4Andor Technology, 5Division of Orthopaedic Surgery, University of California Los Angeles David Geffen School of Medicine

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Neste protocolo, descrevemos como utilizar [18F]-2-fluoro-2-deoxy-D-glucose tomografia por emissão de pósitrons e tomografia computadorizada (18F-FDG PET-CT), imagem latente para medir a resposta metabólica do tumor para a terapia-alvo MLN0128 em um Kras/Lkb1 rato mutante modelo de câncer de pulmão e juntamente com autoradiografia ex vivo de alta resolução e histologia quantitativa de imagem.

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Cancer Research edição 137 18F-FDG PET imagem latente câncer de pulmão glicólise LKB1 KRAS mTOR
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