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Journal / Cancer Research / Udnytte 18F-FDG PET/CT billeddannelse og…
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Cancer Research

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JoVE Journal Cancer Research
Udnytte 18F-FDG PET/CT billeddannelse og kvantitative histologi at måle dynamiske ændringer i glukose stofskifte i musemodeller af lungekræft
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Udnytte 18F-FDG PET/CT billeddannelse og kvantitative histologi at måle dynamiske ændringer i glukose stofskifte i musemodeller af lungekræft

Article DOI: 10.3791/57167-v • 06:51 min • July 21st, 2018
July 21st, 2018 •
1, 2, 3, 3, 3, 1, 4, 5, 1
1Division of Pulmonary and Critical Care Medicine, University of California Los Angeles David Geffen School of Medicine, 2University of North Carolina at Chapel Hill, 3Department of Molecular and Medical Pharmacology, University of California Los Angeles, 4Andor Technology, 5Division of Orthopaedic Surgery, University of California Los Angeles David Geffen School of Medicine

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I denne protokol beskriver vi, hvordan du udnytter [18F]-2-fluoro-2-deoxy-D-glucose positron emissions tomografi og computertomografi (18F-FDG PET/CT) scanning for at måle den tumor metaboliske respons til de målrettede terapi MLN0128 i en Kras/Lkb1 mutant musen model af lungekræft og koblede imaging med høj opløsning ex vivo Autoradiografi og kvantitative histologi.

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Kræftforskning sag 137 18F-FDG PET billedbehandling lungekræft glykolyse LKB1 KRAS mTOR
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