A subscription to JoVE is required to view this content. Sign in or start your free trial.
1Research and Innovation Unit, RHU BioArt Lung 2020,Marie Lannelongue Hospital, 2Phenotypic and Biomarker Core Laboratory, Cardiovascular Institute,Stanford University, 3Department of pathology,Marie Lannelongue Hospital, 4Department of pathology,UCSF School of Medicine, 5Department of thoracic surgery, Hopital Nord, APHM,Aix-Marseille University
Chapters
- 00:04Introduction
- 00:39Catheter Placement
- 01:44Echocardiography
- 02:19Right Heart Catheterization and Pressure Volume Loop Acquisition
- 03:20Acute Right Heart Failure Induction
- 03:58Pressure Overload with Iterative Pulmonary Embolism Induction
- 04:40Systemic Hemodynamic Restoration
- 05:30Results: Representative Acute Right Heart Failure Phenotype Analyses
- 07:07Conclusion
Apresentamos um protocolo para induzir e fenótipo uma insuficiência cardíaca direita aguda em um grande modelo animal com hipertensão pulmonar crônica. Este modelo pode ser usado para testar intervenções terapêuticas, desenvolver métricas cardíacas certas ou para melhorar a compreensão da fisiopatologia aguda de insuficiência cardíaca direita.
Tags
Acute Right Heart FailureChronic Thromboembolic Pulmonary HypertensionLarge Animal ModelInductionPhenotypingVolume OverloadPressure OverloadSeldinger MethodJugular VeinFemoral ArteryFemoral VeinBalloon Dilation CatheterEchocardiographyRight Heart CatheterizationSwan-Ganz CatheterThermodilutionPressure-volume Loop
