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1Research and Innovation Unit, RHU BioArt Lung 2020,Marie Lannelongue Hospital, 2Phenotypic and Biomarker Core Laboratory, Cardiovascular Institute,Stanford University, 3Department of pathology,Marie Lannelongue Hospital, 4Department of pathology,UCSF School of Medicine, 5Department of thoracic surgery, Hopital Nord, APHM,Aix-Marseille University
Chapters
- 00:04Introduction
- 00:39Catheter Placement
- 01:44Echocardiography
- 02:19Right Heart Catheterization and Pressure Volume Loop Acquisition
- 03:20Acute Right Heart Failure Induction
- 03:58Pressure Overload with Iterative Pulmonary Embolism Induction
- 04:40Systemic Hemodynamic Restoration
- 05:30Results: Representative Acute Right Heart Failure Phenotype Analyses
- 07:07Conclusion
Presentamos un protocolo para inducir y fenotipar una insuficiencia cardíaca derecha aguda en un modelo animal grande con hipertensión pulmonar crónica. Este modelo se puede utilizar para probar intervenciones terapéuticas, para desarrollar métricas del corazón derecho o para mejorar la comprensión de la fisiopatología de la insuficiencia cardíaca derecha aguda.
Tags
Acute Right Heart FailureChronic Thromboembolic Pulmonary HypertensionLarge Animal ModelInductionPhenotypingVolume OverloadPressure OverloadSeldinger MethodJugular VeinFemoral ArteryFemoral VeinBalloon Dilation CatheterEchocardiographyRight Heart CatheterizationSwan-Ganz CatheterThermodilutionPressure-volume Loop
