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Journal / Cancer Research / Risonanza di superficie-enhanced Raman Scattering …
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Cancer Research

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JoVE Journal Cancer Research
Risonanza di superficie-enhanced Raman Scattering Nanosonda Ratiometry per la rilevazione di cancro ovarico microscopico tramite ricevitore di folato di Targeting
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Risonanza di superficie-enhanced Raman Scattering Nanosonda Ratiometry per la rilevazione di cancro ovarico microscopico tramite ricevitore di folato di Targeting

Article DOI: 10.3791/58389-v • 07:54 min • March 25th, 2019
March 25th, 2019 •
1, 1, 1, 1,2, 1, 1,3,4,5,6,7
1Department of Radiology, Memorial Sloan Kettering Cancer Center, 2Department of Chemistry, The Graduate Center of the City University of New York, 3Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, 4Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center, 5Gerstner Sloan Kettering Graduate School of Biomedical Sciences, 6Department of Radiology, Weill Cornell Medical College of Cornell University, 7Dana-Farber Cancer Institute and Harvard Medical Center

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Cancro ovarico forma metastasi durante la cavità peritoneale. Qui, presentiamo un protocollo per rendere e uso folato-recettore mirati a risonanza superficie-enhanced Raman scattering nanosonde che rivelano queste lesioni con formazione immagine di alta specificità via raziometrici. Le nanosonde sono amministrati intraperitonealmente ai topi vivi, e le immagini derivate correlano bene con l'istologia.

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Ricerca sul cancro problema 145 Raman SERS nanoparticelle imaging molecolare cancro ovarico recettore per acido folico ratiometry
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