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Overflade-forstærket resonans Raman spredning Nanoprobe Ratiometry til påvisning af mikroskopiske æggestokkræft via folat Receptor målretning
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1Department of Radiology,Memorial Sloan Kettering Cancer Center, 2Department of Chemistry,The Graduate Center of the City University of New York, 3Molecular Pharmacology Program,Memorial Sloan Kettering Cancer Center, 4Center for Molecular Imaging and Nanotechnology (CMINT),Memorial Sloan Kettering Cancer Center, 5Gerstner Sloan Kettering Graduate School of Biomedical Sciences, 6Department of Radiology,Weill Cornell Medical College of Cornell University, 7Dana-Farber Cancer Institute and Harvard Medical Center
Chapters
- 00:05Title
- 00:42Gold Nanostar Core Synthesis
- 01:44Silica Shell Formation
- 03:21Surface Functionalization
- 04:52Nanoprobe Injection and Imaging
- 06:13Results: Representative Surface-enhanced Resonance Raman Scattering (SERRS) Nanoprobe Analyses
- 07:21Conclusion
Kræft i æggestokkene danner metastaser i hele bughulen. Her præsenterer vi en protokol til at foretage og brug folat-receptor målrettet overflade-forstærket resonans Raman spredning nanoprobes, der afslører disse læsioner med høj specificitet via ratiometric imaging. Nanoprobes er blevet administreret intraperitoneal til levende mus, og de afledte billeder korrelere godt med histologi.
