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Overflaten forbedret resonans Raman spredning Nanoprobe Ratiometry for å oppdage mikroskopiske eggstokkreft via folat reseptor målretting
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1Department of Radiology,Memorial Sloan Kettering Cancer Center, 2Department of Chemistry,The Graduate Center of the City University of New York, 3Molecular Pharmacology Program,Memorial Sloan Kettering Cancer Center, 4Center for Molecular Imaging and Nanotechnology (CMINT),Memorial Sloan Kettering Cancer Center, 5Gerstner Sloan Kettering Graduate School of Biomedical Sciences, 6Department of Radiology,Weill Cornell Medical College of Cornell University, 7Dana-Farber Cancer Institute and Harvard Medical Center
Chapters
- 00:05Title
- 00:42Gold Nanostar Core Synthesis
- 01:44Silica Shell Formation
- 03:21Surface Functionalization
- 04:52Nanoprobe Injection and Imaging
- 06:13Results: Representative Surface-enhanced Resonance Raman Scattering (SERRS) Nanoprobe Analyses
- 07:21Conclusion
Eggstokkreft danner metastaser i bukhulen. Her presenterer vi en protokoll for å gjøre og bruk folat-reseptor målrettet overflaten forbedret resonans Raman spredning nanoprobes som avslører disse lesjoner med høy spesifisitet via ratiometric bildebehandling. Nanoprobes administreres intraperitoneally til levende mus og avledede bildene korrelerer med histology.
