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Journal / Engineering / 利用磁性纳米粒子丰富和扩大罕见抗原特异性 t…
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Engineering

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JoVE Journal Engineering
利用磁性纳米粒子丰富和扩大罕见抗原特异性 t 细胞
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Characterization of Nanocrystal Size Distribution using Raman Spectroscopy with a Multi-particle Phonon Confinement Model
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利用磁性纳米粒子丰富和扩大罕见抗原特异性 t 细胞

Article DOI: 10.3791/58640-v • 09:28 min • November 17th, 2018
November 17th, 2018 •
1,2,3,4, 2,4
1Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 2Institute for Cell Engineering, School of Medicine, Johns Hopkins University, 3Institute for Nanobiotechnology, Johns Hopkins University, 4Department of Pathology, School of Medicine, Johns Hopkins University

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抗原特异性 t 细胞由于其频率极低, 很难在治疗中表征或利用。在此, 我们提供了一个协议, 以开发一个磁性粒子, 它可以结合到抗原特异性 t 细胞, 以丰富这些细胞, 然后扩大他们的几百倍, 用于表征和治疗。

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工程 第141期 纳米粒子 磁性富集 人工抗原呈现细胞 t 细胞 免疫治疗 癌症 罕见细胞富集 t 细胞膨胀 采用 t 细胞治疗 新抗原 免疫工程 生物工程
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