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Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

DOI:
10.3791/58837-v

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00:08 min

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October 19, 2021

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, , , ,
1University Paris Descartes Hospital Necker-Enfants Malades,Institut Imagine, 2Institut du Cerveau et de la Moelle épinière – ICM,Sorbonne Universités Paris, 3Transylvanian Institute of Neuroscience (TINS)

Chapters

  • 00:04Introduction
  • 00:28Embryo Preparation and Microinjection
  • 02:29Global Activity Analysis
  • 03:48Touch-Evoked-Escape-Response (TEER)
  • 04:55Zebrafish Larvae Electrophysiology Preparation and Electrophysiological Recording
  • 06:54Results: Representative Zebrafish Larva Brain Field Recording Traces
  • 07:51Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we present a protocol for the development and the characterization of a zebrafish model of epilepsy resulting from the transient inhibition of the DEPDC5 gene.

Tags

Keywords: ZebrafishEpilepsyBehavioral AnalysisPhysiological AnalysisWC5 GeneKnock DownSpontaneous Coiling ActivityVideo TrackingEmbryoAutomated Analysis

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