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The Chick Chorioallantoic Membrane In Vivo Model to Assess Perineural Invasion in Head and Neck Cancer
JoVE Journal
Medicine
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JoVE Journal Medicine
The Chick Chorioallantoic Membrane In Vivo Model to Assess Perineural Invasion in Head and Neck Cancer

The Chick Chorioallantoic Membrane In Vivo Model to Assess Perineural Invasion in Head and Neck Cancer

DOI:
10.3791/59296-v

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09:16 min

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June 21, 2019

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, , , ,
1Periodontics and Oral Medicine,University of Michigan School of Dentistry, 2Pathology,University of Michigan Medical School

Chapters

  • 00:04Title
  • 00:47Egg Incubation and Dorsal Root Ganglion (DRG) Harvest
  • 02:40Egg Preparation for DRG Graft
  • 05:31DRG and Tumor Cell Grafting
  • 06:46Chorioallantoic Membrane (CAM) Harvest
  • 07:48Results: Representative Perineural Invasion Analyses
  • 08:56Conclusion

Summary

Automatic Translation

Automatic Translation

Perineural invasion is an aggressive phenotype for head and neck squamous cell carcinomas and other tumors. The chick chorioallantoic membrane model has been used for studying angiogenesis, cancer invasion, and metastasis. Here we demonstrate how this model can be utilized to assess perineural invasion in vivo.

Tags

Keywords: Chick Chorioallantoic MembraneIn Vivo ModelPerineural InvasionHead And Neck CancerDorsal Root GangliaNerve InvasionCancer PhenotypesFertilized EggsSpinal CordFluorescent Dye

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