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JoVE Journal
Developmental Biology

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In vitro Neuromuscular Junction Induced from Human Induced Pluripotent Stem Cells
 

In vitro Neuromuscular Junction Induced from Human Induced Pluripotent Stem Cells

Article doi: 10.3791/61396
December 3rd, 2020

Summary December 3rd, 2020

Here we provide a protocol to generate in vitro NMJs from human induced pluripotent stem cells (iPSCs). This method can induce NMJs with mature morphology and function in 1 month in a single well. The resulting NMJs could potentially be used to model related diseases, to study pathological mechanisms or to screen drug compounds for therapy.

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