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Cancer Research

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JoVE Journal Cancer Research
Prever em cargas entrega Vivo usando uma Tumor-barreira sangue-cérebro em um prato
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Prever em cargas entrega Vivo usando uma Tumor-barreira sangue-cérebro em um prato

Article DOI: 10.3791/59384-v • 13:34 min • April 16th, 2019
April 16th, 2019 •
1, 1,2, 1,3
1Research Programs Unit, Translational Cancer Medicine Research Program, University of Helsinki, 2Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, 3Laboratory Animal Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki

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Direcionamento de drogas para tumores do sistema nervoso central é um grande desafio. Aqui descrevemos um protocolo para produzir um mímico in-vitro do tumor-barreira sangue-cérebro usando células murino e/ou humanas e discutir sua relevância para a previsibilidade do sistema nervoso central tumor direcionamento em vivo.

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Cancer Research edição 146 tumor-barreira sangue-cérebro glioblastoma transporte intercelular imagens in vivo nanopartículas permeabilidade endotelial peptídeo CooP alvejando o tumor culturas co astrócitos diferenciação de células endoteliais
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