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功能化单有机硼化合物共轭法高效合成全碳第四纪中心
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JoVE Journal Chemistry
Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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功能化单有机硼化合物共轭法高效合成全碳第四纪中心

DOI:
10.3791/59775-v

•

07:50 min

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May 26, 2019

•

, ,
1Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering,California Institute of Technology, 2Department of Chemistry,Bucknell University

Chapters

  • 00:04Title
  • 00:32Functionalized Monoorganozinc Bromide Formation and Monoorganozinc Bromide Conjugate Addition to α,β-Unsaturated Ketones
  • 02:26Extraction Work-up and Purification
  • 05:44Results: Data Analysis and Reaction Scope
  • 07:19Conclusion

Summary

Automatic Translation

Automatic Translation

提出了一种将功能化的单有机酶溴有效地结合在环α、β-不饱和碳基中的全碳第四纪中心的简单实用的协议。

Tags

Copper-mediated Conjugate AdditionMonoorganozinc BromidesCyclic Alpha-beta-unsaturated CarbonylsQuaternary CentersDimethylacetamideOrganobromidesOrganozinc FormationSilyl Enol EtherHydrolysis

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