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Journal / Genetics / Karakteriserer mutational Load og klonal…
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Genetics

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JoVE Journal Genetics
Karakteriserer mutational Load og klonal sammensetning av humant blod
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Karakteriserer mutational Load og klonal sammensetning av humant blod

Article DOI: 10.3791/59846-v • 07:58 min • July 11th, 2019
July 11th, 2019 •
1, 1, 1, 1
1Princess Máxima Center for Pediatric Oncology

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Somatiske mutasjon mønstre i cellene reflekterer tidligere mutagent eksponering og kan avdekke utviklingsmessige avstamning relasjoner. Presentert her er en metodikk for å katalogisere og analysere somatiske mutasjoner i individuelle blodkreft stammen og stamceller.

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Genetikk hematopoiesen celleklonalitet somatiske mutasjoner utvikling avstamning tracing mutational signaturer leukemi
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