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Vurdering af langvarig depression induktion i voksne cerebellar skiver
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Assessment of Long-term Depression Induction in Adult Cerebellar Slices
DOI:

09:30 min

October 16, 2019

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Chapters

  • 00:04Title
  • 00:50Brain Dissection and Trimming
  • 02:52Brain Slicing
  • 04:10Whole-Cell Patch-Clamp Recording
  • 06:10Long Term Depression (LTD) Induction
  • 07:12Results: Representative Purkinje Cell Voltage and Current Traces During Conjunctive Stimulation
  • 08:44Conclusion

Summary

Automatic Translation

I nogle genmanipulerede dyr, ved hjælp af en enkelt protokol kan undlade at fremkalde LTD i cerebellar Purkinje celler, og der kan være en uoverensstemmelse mellem LTD og motor læring. Flere protokoller er nødvendige for at vurdere LTD-induktion i genmanipulerede dyr. Standard protokoller vises.

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