A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

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JoVE Journal Medicine

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

DOI:

10.3791/61158-v

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05:14 min

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May 16, 2020

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Yihai Liu, Wenfeng Zhang, Tingting Hu, Jie Ni, Biao Xu, Wei Huang

¹Department of Cardiology, Nanjing Drum Tower Hospital,Clinical College of Nanjing Medical University

Chapters

00:04Introduction
00:31Preparation of the Reagents and Animals
01:02Establishment of DCM Animal Model
01:43Echocardiographic Examination
02:13Histological Staining
03:30Results: Dox Induces Dilated Cardiomyopathy
04:35Conclusion

Summary

Automatic Translation

Described is a protocol to establish a Doxorubicin-induced dilated cardiomyopathy (DCM) model in mice via long-term intraperitoneal injection of Doxorubicin.

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

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