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Cancer Research

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JoVE Journal Cancer Research
Orthotope Transplantation von Brusttumoren als präklinische Modelle für Brustkrebs
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Orthotope Transplantation von Brusttumoren als präklinische Modelle für Brustkrebs

Article DOI: 10.3791/61173-v • 07:45 min • May 18th, 2020
May 18th, 2020 •
*1,2,3, *1,2,3, 1,2,3, 1,2,3, 1,2,3, 1,2,3
1Department of Molecular and Cellular Biology, Baylor College of Medicine, 2Lester and Sue Smith Breast Center, Baylor College of Medicine, 3Dan L. Duncan Cancer Center, Baylor College of Medicine
* These authors contributed equally

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Patientenbasierte Xenograft-Modelle (PDX) und transplantierbare gentechnisch veränderte Mausmodelle rekapitulieren menschliche Krankheiten originalgetreu und sind bevorzugte Modelle für die grundlegende und translationale Brustkrebsforschung. Hier wird eine Methode beschrieben, Brusttumorfragmente orthotopisch in das Brustfettpolster zu transplantieren, um die Tumorbiologie zu untersuchen und die Arzneimittelreaktion zu bewerten.

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Cancer Research Brustkrebs präklinisches Modell Brustfettpolstertransplantation Tumorbiologie Arzneimittelreaktion Biomarker
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