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Ortotopisk transplantation af brysttumorer som prækliniske modeller for brystkræft
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
DOI:

07:45 min

May 18, 2020

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Chapters

  • 00:04Introduction
  • 01:22Cryopreserved Mammary Tumor Fragment Preparation
  • 02:23Fresh Mammary Tumor Sample Collection and Preparation
  • 03:28Surgical Preparation
  • 04:04Tumor Fragment Transplantation
  • 06:26Results: Representative Transplant Tumor Characterization
  • 06:54Conclusion

Summary

Automatic Translation

Patient-afledte xenograft (PDX) modeller og transplanterbare genetisk manipulerede musemodeller trofast rekapitulere menneskelige sygdomme og er foretrukne modeller for grundlæggende og translationel brystkræft forskning. Her, en metode er beskrevet til ortotopisk transplantere brysttumor fragmenter i bryst fedt pad til at studere tumor biologi og evaluere lægemiddelrespons.

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