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低强度冲击波模型用于啮齿动物闭头轻度创伤性脑损伤的临床前评估
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents
DOI:

06:09 min

November 06, 2020

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Chapters

  • 00:04Introduction
  • 00:53Installation of the Blast TBI Setup
  • 01:34Preparation of Experimental Setup and Induction of Mild TBI in Rodents
  • 03:06Exposure of Rodent to Blast Wave and its Recovery
  • 03:59Results: Acute In-Vivo Effects of Blast-Induced TBI
  • 05:28Conclusion

Summary

Automatic Translation

我们在这里提出了啮齿动物冲击波模型的方案,以研究轻度至中度创伤性脑损伤的神经生物学和病理生理学影响。我们建立了一个气体驱动的台式设置,配备了压力传感器,允许可靠和可重复地产生爆炸引起的轻度至中度创伤性脑损伤。

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