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JoVE Journal Behavior
En kronisk søvnfragmenteringsmodel, der bruger vibrerende orbital rotor til at fremkalde kognitivt underskud og angstlignende adfærd hos unge mus af vildtype
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En kronisk søvnfragmenteringsmodel, der bruger vibrerende orbital rotor til at fremkalde kognitivt underskud og angstlignende adfærd hos unge mus af vildtype

Article DOI: 10.3791/61531-v • 06:23 min • September 22nd, 2020
September 22nd, 2020 •
1, 1, 1, 1, 1, 1, 1, 1,2, 1,3
1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China, 2Key Laboratory of Neurological Diseases of Chinese Ministry of Education, The School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000,China, 3Department of Pharmacology, School of Basic Medical Science; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China

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Præsenteret her er en protokol for kronisk søvn fragmentering (CSF) model opnået ved en elektrisk kontrolleret orbital rotor, som kunne fremkalde bekræftet kognitivt underskud og angst-lignende adfærd hos unge vilde-type mus. Denne model kan anvendes til at udforske patogenese af kronisk søvnforstyrrelser og relaterede lidelser.

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Adfærd Problem 163 kronisk søvnfragmentering orbital rotor kognitivt underskud angstlignende adfærd obstruktiv søvnapnø neurodegenerative sygdomme
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