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Optimization of Radiochemical Reactions using Droplet Arrays
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JoVE Journal Chemistry
Optimization of Radiochemical Reactions using Droplet Arrays

Optimization of Radiochemical Reactions using Droplet Arrays

DOI:
10.3791/62056-v

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10:54 min

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February 12, 2021

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, , ,
1Physics and Biology in Medicine Interdepartmental Graduate Program,University of California Los Angeles (UCLA), 2Crump Institute of Molecular Imaging,UCLA, 3Department of Molecular & Medical Pharmacology,David Geffen School of Medicine, 4Department of Bioengineering,UCLA

Chapters

  • 00:05Introduction
  • 01:00Planning and Optimizing the Study
  • 01:37Preparation of Reagents and Materials for Optimizing the Radiosynthesis of [18F]Fallypride
  • 03:11Parallel Synthesis of [18F]Fallypride with Different Precursor Concentrations
  • 06:02Synthesis Analysis to Determine Reaction Performance and Optimal Conditions
  • 08:55Results: Influence of Precursor Concentration on the Microdroplet Synthesis of [18F]Fallypride
  • 10:08Conclusion

Summary

Automatic Translation

Automatic Translation

This method describes the use of a novel high-throughput methodology, based on droplet chemical reactions, for the rapid and economical optimization of radiopharmaceuticals using nanomole amounts of reagents.

Tags

Keywords: Radiochemical ReactionsDroplet ArraysAutomated Radio SynthesizersFDGPrecursor ConcentrationFallyprideMicrodroplet ChipsPhotolithographyThexyl AlcoholAcetonitrileSerial DilutionsCrude Reaction ProductCollection SolutionFluoride Stock Solution

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