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Udvikling af en cellekokulturmodel til efterligning af hjerteiskæmi /reperfusion in vitro
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Udvikling af en cellekokulturmodel til efterligning af hjerteiskæmi /reperfusion in vitro

Article DOI: 10.3791/62913-v • 08:05 min • October 13th, 2021
October 13th, 2021 •
1, 1, 1, 1,2,3
1Department of Anesthesiology, Vanderbilt University Medical Center, 2Anesthesiology, TVHS VA Medical Center, 3Department of Pharmacology, Vanderbilt University

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Rumlig afstand er en nøgleparameter i vurderingen af hypoxi / reoxygeneringsskade i en co-kulturmodel af separate endotel- og kardiomyocytcellelag, hvilket for første gang tyder på, at optimering af co-kulturens rumlige miljø er nødvendig for at tilvejebringe en gunstig in vitro-model til test af endotelcellernes rolle i kardiomyocytbeskyttelse.

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