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October 04, 2021
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Rodent models of L-DOPA-induced dyskinesias are invaluable tools to identify therapeutic interventions to attenuate the development or alleviate the manifestations that emerge due to the repeated administration of L-DOPA. This protocol demonstrates how to induce and analyze dyskinetic-like movements in the unilaterally 6-OHDA-lesioned rat model of Parkinson's disease.
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Bariotto-dos-Santos, K., Ribeiro, D. L., Guimarães, R. P., Padovan-Neto, F. E. Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease. J. Vis. Exp. (176), e62924, doi:10.3791/62924 (2021).
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