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Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
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Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Article DOI: 10.3791/62924-v • 06:45 min • October 4th, 2021
October 4th, 2021 •
*1, *1, 1, 1
1Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo
* These authors contributed equally

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Summary
Automatic Translation

Rodent models of L-DOPA-induced dyskinesias are invaluable tools to identify therapeutic interventions to attenuate the development or alleviate the manifestations that emerge due to the repeated administration of L-DOPA. This protocol demonstrates how to induce and analyze dyskinetic-like movements in the unilaterally 6-OHDA-lesioned rat model of Parkinson's disease.

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L-DOPA-induced Dyskinesias 6-OHDA-lesioned Rat Model Parkinson's Disease Preclinical Tool Antidyskinetic Interventions Sprague-Dawley Male Rats Norepinephrine Transporter Inhibitor Anesthesia Stereotaxic Apparatus Microinjection Skull Region Medial Forebrain Bundle (MFB) Bregma Lambda 6-hydroxydopamine (6-OHDA) Microliters
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