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JoVE Journal Biology
Human lever mikrofysiologisk system til vurdering af lægemiddelinduceret levertoksicitet in vitro
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Human lever mikrofysiologisk system til vurdering af lægemiddelinduceret levertoksicitet in vitro

Article DOI: 10.3791/63389-v • 11:06 min • January 31st, 2022
January 31st, 2022 •
1, 1, 1, 1, 1, 1
1CN Bio Innovations Ltd

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Lægemiddelinduceret leverskade (DILI) er en væsentlig årsag til lægemiddelsvigt. En protokol er udviklet til nøjagtigt at forudsige DILI-ansvaret for en forbindelse ved hjælp af et levermikrofysiologisk system (MPS). Levermodellen bruger kokultur af primære leverceller og translationelt relevante endepunkter til at vurdere cellulære reaktioner på behandlingen.

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Biologi udgave 179
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