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Chapters
- 00:05Introduction
- 00:53Microphysiological System (MPS) Set-Up and Priming (Day -1)
- 02:14Seeding Liver Cells into MPS on Day 0
- 06:00Media Collection, Media Change and Drug Dosing (Days 4 and 6), and Ending the Experiment (Day 8)
- 07:52Results: Assessment of Liver Microtissues After the Treatment with Various Drugs
- 10:22Conclusion
Drug-induced liver injury (DILI) is a major cause of drug failure. A protocol has been developed to accurately predict the DILI liability of a compound using a liver microphysiological system (MPS). The liver model uses the coculture of primary hepatic cells and translationally relevant endpoints to assess cellular responses to treatment.
