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Lægemiddelbehandling ved central venekateter i en musemodel af angiotensin II induceret abdominal aortaaneurisme og overvågning ved 3D-ultralyd
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Lægemiddelbehandling ved central venekateter i en musemodel af angiotensin II induceret abdominal aortaaneurisme og overvågning ved 3D-ultralyd

Article DOI: 10.3791/64124-v • 10:09 min • August 4th, 2022
August 4th, 2022 •
1, 1, 1, 2,3, 4, 5, 1, 1, 1
1Division of Vascular Surgery, Department of General Surgery, Medical University of Vienna and Vienna General Hospital, 2Leeds Institute for Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, 3Leeds Vascular Institute, Leeds General Infirmary, 4Department for Visceral, Thoracic and Vascular Surgery, Technical University of Dresden and University Hospital Carl-Gustav Carus, 5Division of Cardiovascular and Interventional Radiology, Division of Molecular and Gender Imaging, Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna and Vienna General Hospital

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Denne protokol beskriver den på hinanden følgende implantation af en osmotisk pumpe for at inducere abdominal aortaaneurisme ved angiotensin II-frigivelse i apolipoprotein E (ApoE) mangelfulde mus og af en vaskulær adgangsport med et jugular venekateter til gentagen lægemiddelbehandling. Overvågning af aneurismeudvikling ved 3D-ultralyd udføres effektivt på trods af dorsale implantater.

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