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Entschlüsselung der hochauflösenden 3D-Chromatinorganisation über Capture Hi-C
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Entschlüsselung der hochauflösenden 3D-Chromatinorganisation über Capture Hi-C

Article DOI: 10.3791/64166-v • 09:32 min • October 14th, 2022
October 14th, 2022 •
1, 1, 2, 1, 3, 4, 1, 1,5
1EMBL: European Molecular Biology Laboratory, 2Institut Curie, 3Agilent Technologies, 4Genmab BV, 5Collège de France

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Dieses Protokoll beschreibt die Capture Hi-C-Methode, die verwendet wird, um die 3D-Organisation von megabasierten Zielgenomregionen mit hoher Auflösung zu charakterisieren, einschließlich der Grenzen topologisch assoziierender Domänen (TADs) und langreichweitiger Chromatininteraktionen zwischen regulatorischen und anderen DNA-Sequenzelementen.

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Widerruf Heft 188
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