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Journal / Neuroscience / Musmodeller av periventrikulär Leukomalacia
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Neuroscience

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JoVE Journal Neuroscience
Musmodeller av periventrikulär Leukomalacia
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Musmodeller av periventrikulär Leukomalacia

Article DOI: 10.3791/1951-v • 06:24 min • May 18th, 2010
May 18th, 2010 •
1, 1, 1
1Department of Cell Biology and Human Anatomy Institute for Pediatric Regenerative Medicine School of, University of California, Davis

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Vi etablerade musmodeller av periventrikulär leukomalacia (PVL), det dominerande hjärnskada hos prematura barn kännetecknas av periventrikulär vita substansen lesioner. Hypoxi / ischemi med / utan systemisk infektion är de främsta orsakerna till PVL. Ensidig halspulsådern ligatur och hypoxi exponering med / utan lipopolysackarid injektion skapar PVL-liknande lesioner i P6 möss.

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JUPITER neurovetenskap hjärna mus vita substansen skada oligodendrocyte periventrikulär leukomalacia
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