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Journal / Immunology and Infection / Transnuclear Möss med fördefinierade Receptor T…
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Immunology and Infection

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JoVE Journal Immunology and Infection
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Transnuclear Möss med fördefinierade Receptor T cellspecifika Against Toxoplasma gondii Erhållits via SCNT

Article DOI: 10.3791/2168-v • 13:37 min • September 30th, 2010
September 30th, 2010 •
1, 1, 1,2, 1, 1,3, 1,3
1Whitehead Institute for Biomedical Research, 2Departments of Microbiology and Biological Sciences, National University of Singapore, 3Department of Biology, Massachusetts Institute of Technology

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Vi visar här att epigenetiska omprogrammering via somatisk kärnöverföring (SCNT) kan användas som ett verktyg för att generera musmodeller med fördefinierade T cell receptor (TCR) särdrag. Dessa transnuclear möss uttrycka motsvarande TCR från deras endogena lokus under kontroll av den endogena arrangören.

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Utvecklingsbiologi SCNT immunologi TCR BCR musmodell transnuclear
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