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Biology

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JoVE Journal Biology
Force Measurement During Contraction to Assess Muscle Function in Zebrafish Larvae
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Force Measurement During Contraction to Assess Muscle Function in Zebrafish Larvae

Article DOI: 10.3791/50539-v • 08:25 min • July 23rd, 2013
July 23rd, 2013 •
1, 1,2, 3, 1,4
1Department of Biomedical Engineering, University of Michigan, 2Department of Surgery, Section of Plastic Surgery, University of Michigan, 3Departments of Pediatrics and Neurology, University of Michigan, 4Department of Molecular and Integrative Physiology, University of Michigan

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Summary
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Force measurements can be used to demonstrate changes in muscle function due to development, injury, disease, treatment or chemical toxicity. In this video, we demonstrate a method to measure force during a maximal contraction of zebrafish larval trunk muscle.

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Force Measurement Contraction Muscle Function Zebrafish Larvae Muscle Development Muscle Disease Chemical Toxicity Video Article Salt Solution Force Transducer Length Controller Isometric Twitch Contraction Electric Field Stimulation Muscle Health Genetically Modified Larvae Drugs Toxicants Muscle Disease Models Treatments Muscle Development Injury Chemical Toxicity
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