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Ekspression af exogen cytokin i patient-afledte xenotransplantater via injektion med en cytokin-transduceret stromalcellelinie
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Ekspression af exogen cytokin i patient-afledte xenotransplantater via injektion med en cytokin-transduceret stromalcellelinie

Article DOI: 10.3791/55384-v • 12:58 min • May 10th, 2017
May 10th, 2017 •
1, 1, 1, 2, 3, 1, 1, 1
1Department of Pathology and Human Anatomy, Loma Linda University, 2Department of Basic Sciences, Loma Linda University, 3Department of Medicine, Loma Linda University

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Beskrevet her er en fremgangsmåde til fremstilling af eksogent cytokin i patient-afledte xenograftmus (PDX) via ugentlig intraperitoneal injektion af en cytokin-transduceret stromalcellelinie. Denne metode udvider anvendeligheden af ​​PDX og giver mulighed for transient eller vedvarende eksogen cytokinlevering i en lang række PDX-modeller.

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Medicin udgave 123 xenograft præklinisk model leukæmi patient-afledte xenotransplantater (PDX), thymisk stromal lymfopoietin (TSLP)
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