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Journal / Medicine / Optimalisert LC--MS-/ MS metoden for høy…
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JoVE Journal Medicine
Optimalisert LC--MS-/ MS metoden for høy gjennomstrømming analyse av klinisk prøver av Ivacaftor, store metabolitter og Lumacaftor i biologiske væsker Cystic Fibrosis pasienter
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Optimalisert LC--MS-/ MS metoden for høy gjennomstrømming analyse av klinisk prøver av Ivacaftor, store metabolitter og Lumacaftor i biologiske væsker Cystic Fibrosis pasienter

Article DOI: 10.3791/56084-v • 06:14 min • October 15th, 2017
October 15th, 2017 •
1, 1, 1,2, 1
1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 2Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University

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Ivacaftor og ivacaftor-lumacaftor er to nye CF stoffer. Men er det fortsatt en mangel på forståelse på PK/PD og farmakologi. Vi presenterer en optimalisert HPLC-MS teknikk for samtidige analyse av ivacaftor og dens viktigste metabolitter og lumacaftor.

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Medisin problemet 128 Ivacaftor lumacaftor HPLC-MS cystisk fibrose plasma sputum biologiske væsker
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