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Journal / Cancer Research / 纳米颗粒对荷瘤小鼠药相结合的样品提取及同时色谱定量分析…
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JoVE Journal Cancer Research
纳米颗粒对荷瘤小鼠药相结合的样品提取及同时色谱定量分析
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纳米颗粒对荷瘤小鼠药相结合的样品提取及同时色谱定量分析

Article DOI: 10.3791/56159-v • 08:57 min • October 5th, 2017
October 5th, 2017 •
1, 1, 1, 1, 1, 2, 1, 1
1Department of Pharmaceutical Sciences, University of Toronto, 2Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario Cancer Institute, University Health Network

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该协议描述了一个高效和方便的分析过程中的样品提取和同时测定多药, 阿霉素 (DOX), 丝裂霉 C (MMC) 和心脏毒性 DOX 代谢物, doxorubicinol (DOXol), 在生物样品的临床前乳腺癌模型治疗的纳米颗粒制剂的协同药物组合。

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癌症研究 问题 128 HPLC 同时分析 生物样品提取 联合化疗 纳米颗粒 药代动力学 生物分布 阿霉素 丝裂霉素 C doxorubicinol 血液 肿瘤
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