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Cancer Research

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JoVE Journal Cancer Research
Generation af høj overførselshastighed tredimensionale Tumor Spheroids for narkotika-Screening
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Generation af høj overførselshastighed tredimensionale Tumor Spheroids for narkotika-Screening

Article DOI: 10.3791/57476-v • 05:54 min • September 5th, 2018
September 5th, 2018 •
1, 1, 2, 2, 2, 2, 2, 1
1Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research, 2Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research

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På tværs af en bred vifte af tegn på sygdom, mere fysiologisk relevante modeller bliver udviklet og implementeret i drug discovery programmer. Den nye modelsystem beskrevet her demonstrerer hvordan tredimensionale tumor spheroids kan kulturperler og screenes i en høj overførselshastighed 1536-godt plade-baseret system til at søge efter nye onkologiske lægemidler.

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Kræftforskning sag 139 Tumor spheroids tre-dimensionelle (3D) multi godt plader stof screening høj overførselshastighed definerede medium
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