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Adeno-associeret Virus-medieret levering af CRISPR for hjerte gen redigering i mus
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Adeno-associeret Virus-medieret levering af CRISPR for hjerte gen redigering i mus

Article DOI: 10.3791/57560-v • 09:00 min • August 2nd, 2018
August 2nd, 2018 •
1, 1, 1, 1
1Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, Ohio State University Wexner Medical Center

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Her giver vi en detaljeret protokol til at udføre i vivo hjerte gen redigering i mus ved hjælp af rekombinante Adeno-Associated Virus (rAAV)-medieret levering af CRISPR. Denne protokol tilbyder en lovende terapeutisk strategi for at behandle dystrofe kardiomyopati i Duchenne muskeldystrofi og kan bruges til at generere hjerte-specifikke knockout i postnatal mus.

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Medicin spørgsmål 138 AAV CRISPR Duchenne muskeldystrofi dystrofin gen redigering mdx rekombinant adeno-associeret virus
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