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Nye metoder for Intranasal Administration Under Inhalation anæstesi til at evaluere næse-til-hjerne Drug Delivery
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Nye metoder for Intranasal Administration Under Inhalation anæstesi til at evaluere næse-til-hjerne Drug Delivery

Article DOI: 10.3791/58485-v • 05:44 min • November 14th, 2018
November 14th, 2018 •
*1, *1, 1, 1
1Laboratory of Pharmaceutics, School of Pharmacy, Nihon University
* These authors contributed equally

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Her beskriver vi to nye metoder til stabil intranasal administration under inhalation anæstesi med minimal fysisk stress for forsøgsdyr. Vi også beskrive en metode til kvantitativ evaluering af narkotika distribution niveauer i hjernen via næse-til-hjerne vej ved hjælp af radiolabeled [14C]-inulinsirup som model substrat af vandopløselige makromolekyler.

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Medicin sag 141 næse til hjernen intranasal administration hjernen distribution hydrofile makromolekyle inhalation anæstesi kvantitativ evaluering
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