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吸入麻醉下鼻内给药评价鼻腔给脑药物的新方法
JoVE Journal
Medicine
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JoVE Journal Medicine
Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
DOI:

05:44 min

November 14, 2018

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Chapters

  • 00:04Title
  • 01:04Intranasal Drug Administration
  • 03:11Radio-Labeled Water-Soluble Macromolecules ([14C]-inulin) Quantification
  • 04:32Results: Comparison of Brain [14C]-Inulin Levels After Two Different Methods of Intranasal Administration
  • 05:17Conclusion

Summary

Automatic Translation

在这里, 我们描述了两种新的方法稳定鼻内给药吸入麻醉与最小的物理压力实验动物。我们还描述了一种方法, 定量评估药物分布水平的药物分布水平通过鼻对大脑的途径使用放射性色标 [14c]-伊努林作为水溶性大分子的模型底物。

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