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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

DOI:
10.3791/59511-v

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09:41 min

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July 19, 2019

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, , , , , , , , , ,
1Department of Neurosciences, Lerner Research Institute,Cleveland Clinic, 2Department of Biomedical Engineering, Lerner Research Institute,Cleveland Clinic, 3Mellen Center for Treatment and Research in Multiple Sclerosis, Neurological Institute,Cleveland Clinic

Chapters

  • 00:04Title
  • 01:29Brain Autopsy
  • 03:44Spinal Cord Autopsy
  • 04:47Pathology
  • 07:11Results: Representative Post-mortem Multiple Sclerosis (MS) Brain and Spinal Cord Characterization
  • 08:52Conclusion

Summary

Automatic Translation

Automatic Translation

Multiple sclerosis is an inflammatory demyelinating disease with no cure. Analysis of brain tissue provides important clues to understanding the pathogenesis of the disease. Here we discuss the methodology and downstream analysis of MS brain tissue collected through a unique rapid autopsy program in operation at the Cleveland Clinic.

Tags

Multiple SclerosisRapid AutopsyIn Situ MRICerebral HemispheresPrimary Motor CortexNeuropathologyNeurodegenerative Disease

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