Journal
/
/
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
JoVE Journal
Behavior
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Behavior
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
DOI:

07:07 min

February 10, 2020

,

Chapters

  • 00:04Title
  • 00:56Weight Drop Traumatic Brain Injury (TBI)
  • 02:01Electroencephalography (EEG) Electrode Implantation Surgical Field Preparation
  • 03:11EEG Electrode Implantation
  • 05:13Results: Representative Spontaneous Seizure Depictions and Timelines
  • 06:17Conclusion

Summary

Automatic Translation

This systematic protocol describes a new animal model of post-traumatic epilepsy after repetitive mild traumatic brain injury. The first part details steps for traumatic brain injury induction using a modified weight drop model. The second part provides instructions on the surgical approach for single- and multi-channel electroencephalographic data acquisition systems.

Related Videos

Read Article