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Valideret LC-MS/MS Panel til kvantificering af 11 resistente TB-medicin i små hårprøver
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Valideret LC-MS/MS Panel til kvantificering af 11 resistente TB-medicin i små hårprøver

Article DOI: 10.3791/60861-v • 08:54 min • May 19th, 2020
May 19th, 2020 •
1, 1, 1, 2, 3, 4, 1
1Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California San Francisco, 2Department of Epidemiology and Biostatistics, University of California San Francisco, 3Department of Medicine, Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, 4Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco

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De nuværende metoder til analyse af patienternes overholdelse af komplekse resistente tuberkulose (DR-TB) regimer kan være unøjagtige og ressourcekrævende. Vores metode analyserer hår, en let indsamlet og lagret matrix, for koncentrationer af 11 DR-TB medicin. Ved hjælp af LC-MS/MS, Vi kan bestemme sub-nanogram narkotika niveauer, der kan udnyttes til bedre at forstå narkotika overholdelse.

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Medicin LC-MS/MS MDR-TB narkotika Hår analyse Overholdelse overvågning Terapeutisk lægemiddelovervågning Resistent TB
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