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经过验证的LC-MS/MS面板,用于在小头发样本中量化11种耐药结核病药物
JoVE Journal
Medicine
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JoVE Journal Medicine
Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples
DOI:

08:54 min

May 19, 2020

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Chapters

  • 00:04Introduction
  • 01:20Hair Sampling
  • 02:32Drug Extraction
  • 04:18Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Preparation
  • 05:35Data Analysis
  • 06:47Results: Representative Drug-Resistant (DR) TB Medication Quantification
  • 07:55Conclusion

Summary

Automatic Translation

目前分析患者是否遵守复杂耐药结核病(DR-TB)方案的方法可能不准确且资源密集。我们的方法分析头发,一个易于收集和储存的基质,浓度为11个DR-TB药物。使用LC-MS/MS,我们可以确定亚纳米格药物水平,可用于更好地了解药物依从性。

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